GITHUB AGENT SKILLS / 技能收录
给你的 AI 助手
装上专业技能
我们从 GitHub 持续收录、审核并分类优质的 Agent Skills，按职业与使用场景整理，复制一行命令即可安装到 Claude Code、Cursor 等智能体。
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Microsoft
@microsoft
openclaw
@openclaw
OpenAI
@openai
The Apache Software Foundation
@apache
GitHub
@github
Anthropic
@anthropics
AutoGPT
@Significant-Gravitas
Garry Tan
@garrytan全部 Skills 196852
tooluniverse-structural-proteomics
Integrate structural biology data with proteomics for drug target validation. Retrieves protein structures from PDB (RCSB, PDBe), AlphaFold predictions, antibody structures (SAbDab), GPCR data (GPCRdb), binding pocket analysis (ProteinsPlus), and ligand interactions (BindingDB). Use when asked to find structures for a drug target, identify binding site ligands, cross-validate drug binding with structural data, assess structural druggability, or compare experimental vs predicted structures.
dotfiles-review
Use to review the ~/.dotfiles tree — rc files, alias/function files under to_source/, home_rcs/, and .config tool dirs — for objective conflicts (duplicate or shadowing aliases, mutually exclusive settings, dead references) and best-practice recommendations, while never opening secret files. Triggers: "review my dotfiles", "clean up my zshrc", "are my aliases conflicting", "modernize my shell config".
tooluniverse-stem-cell-organoid
Research stem cells, iPSCs, organoids, and cell differentiation using ToolUniverse tools. Covers pluripotency marker identification, differentiation pathway analysis, organoid model characterization, cell type annotation, and disease modeling. Integrates CellxGene/HCA for single-cell atlas data, CellMarker for cell type markers, GEO for stem cell datasets, and pathway tools for differentiation signaling. Use when asked about stem cells, iPSCs, organoids, cell reprogramming, pluripotency, differentiation protocols, or 3D culture models.
config-surface-audit
Use to audit the non-skill recurring context surfaces of the AI tools — configured MCP servers (tool schemas load every session), permission allowlists, and hooks in settings.json / config.toml — against actual usage from transcripts, and recommend removing what never fires. Triggers: "audit my MCP servers", "are these permissions stale", "what hooks do I have", "config bloat".
tooluniverse-statistical-modeling
Perform statistical modeling and regression analysis on biomedical datasets. Supports linear regression, logistic regression (binary/ordinal/multinomial), mixed-effects models, Cox proportional hazards survival analysis, Kaplan-Meier estimation, and comprehensive model diagnostics. Extracts odds ratios, hazard ratios, confidence intervals, p-values, and effect sizes. Designed to solve BixBench statistical reasoning questions involving clinical/experimental data. Use when asked to fit regression models, compute odds ratios, perform survival analysis, run statistical tests, or interpret model coefficients from provided data.
audit-skill-hygiene
Use to produce a content-safe, reproducible measurement-only audit of cataloged skill usage from Claude Code and Codex. Emits an aggregate decision matrix; it never changes catalogs or recommends direct archival. Triggers: "audit skill usage", "which skills are actually used", "is our skill catalog bloated".
tooluniverse-spatial-transcriptomics
Analyze spatial transcriptomics data to map gene expression in tissue architecture. Supports 10x Visium, MERFISH, seqFISH, Slide-seq, and imaging-based platforms. Performs spatial clustering, domain identification, cell-cell proximity analysis, spatial gene expression patterns, tissue architecture mapping, and integration with single-cell data. Use when analyzing spatial transcriptomics datasets, studying tissue organization, identifying spatial expression patterns, mapping cell-cell interactions in tissue context, characterizing tumor microenvironment spatial structure, or integrating spatial and single-cell RNA-seq data for comprehensive tissue analysis.
th-tooling
Use for hygiene of this machine's AI-tooling harness — the ~/.dotfiles repo, the ai-bootstrap skills tree, and the installed tool homes (~/.claude, ~/.codex, ~/.gemini): auditing real skill usage from transcripts, archiving unused skills, reviewing dotfiles for conflicting aliases/config, refreshing snapshot state (skill symlinks, submodules, mirrored assets), transcript disk retention, compacting agent memory (AGENTS.md notes, bd memories), and auditing MCP/permission/hook config against actual use. Route to exactly one subskill per task. Triggers: "audit my skills", "which skills are unused", "review my dotfiles", "clean up my zshrc", "refresh snapshots", "old transcripts eating disk", "compact my notes to self", "audit my MCP servers", "harness hygiene".
tooluniverse-spatial-omics-analysis
Computational analysis framework for spatial multi-omics data integration. Given spatially variable genes (SVGs), spatial domain annotations, tissue type, and disease context from spatial transcriptomics/proteomics experiments (10x Visium, MERFISH, DBiTplus, SLIDE-seq, etc.), performs comprehensive biological interpretation including pathway enrichment, cell-cell interaction inference, druggable target identification, immune microenvironment characterization, and multi-modal integration. Produces a detailed markdown report with Spatial Omics Integration Score (0-100), domain-by-domain characterization, and validation recommendations. Uses 70+ ToolUniverse tools across 9 analysis phases. Use when users ask about spatial transcriptomics analysis, spatial omics interpretation, tissue heterogeneity, spatial gene expression patterns, tumor microenvironment mapping, tissue zonation, or cell-cell communication from spatial data.
user-questionnaire
Use to accumulate genuine owner decisions into a local asynchronous review packet, publish that packet as a local web form the owner answers in a browser, walk the owner through it one question at a time, ingest the recorded answers in a later session, or route recorded signoffs through canonical owning workflows. Every problem scope and recommendation receives a separate adversarial verdict from an independent subagent against the target project's th-projects shape and th-engineering bar before it is review-ready. Triggers: "prepare decisions for me to review", "review when I wake up", "publish the questionnaire", "give me a link to review", "walk me through the blocked decisions", "ingest my answers", "collect owner signoffs", "decision packet", "questionnaire".
tooluniverse-small-molecule-discovery
Find, characterize, and source small molecules for chemical biology and drug discovery. Covers compound identification (PubChem, ChEMBL), structure search, binding affinity data, ADMET/drug-likeness prediction, and commercial availability (eMolecules, Enamine). Use when asked to find compounds, assess drug-likeness, search by structure, retrieve binding affinities, or source chemicals.
relentless-vision-pursuit
Use for a recurring, generative pursuit run that closes the gap between what a project is today and the ideal its doctrine describes: lane-sequenced audits of every surface against the applicable quality bar, vision-grounded ideation lenses, synthesis into a ranked move list with tier-board movement across runs, and a gated (never auto-released) work plan. Triggers: "run the vision pursuit", "what's the next best step toward the vision", "relentlessly improve this project", "audit the whole project against the ideal", "generate the next round of improvements".
spec-and-spine
Use when consulting the capability spec pillar in this mature-layout fixture.
tooluniverse-single-cell
Use when analyzing single-cell RNA-seq expression matrices, clustering cells, annotating cell types, or studying cell-cell communication.
legends-and-lore
Use when consulting the design contract pillar in this mature-layout fixture.
lay-and-land
Use when consulting the topology pillar in this mature-layout fixture.
tooluniverse-sequence-retrieval
Retrieves biological sequences (DNA, RNA, protein) from NCBI and ENA with gene disambiguation, accession type handling, and comprehensive sequence profiles. Creates detailed reports with sequence metadata, cross-database references, and download options. Use when users need nucleotide sequences, protein sequences, genome data, or mention GenBank, RefSeq, EMBL accessions.
heart-and-soul
Use when consulting the doctrine pillar in this mature-layout fixture.