GITHUB AGENT SKILLS / 技能收录
给你的 AI 助手
装上专业技能
我们从 GitHub 持续收录、审核并分类优质的 Agent Skills，按职业与使用场景整理，复制一行命令即可安装到 Claude Code、Cursor 等智能体。
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Microsoft
@microsoft
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@openclaw
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@openai
The Apache Software Foundation
@apache
GitHub
@github
Anthropic
@anthropics
AutoGPT
@Significant-Gravitas
Garry Tan
@garrytan全部 Skills 196852
tooluniverse-variant-to-mechanism
End-to-end variant-to-mechanism analysis: given a genetic variant (rsID or coordinates), trace its functional impact from regulatory context (GWAS, eQTL, RegulomeDB, ENCODE) through target gene identification (GTEx, OpenTargets L2G) to downstream pathway and disease biology (STRING, Reactome, GO enrichment, disease associations). Produces an evidence-graded mechanistic narrative linking genotype to phenotype. Use when asked "how does this variant cause disease?", "what is the mechanism of rs7903146?", "trace variant to pathway", or "connect this GWAS hit to biology".
finishing-a-development-branch
Use when implementation is complete, all tests pass, and you need to decide how to integrate the work - guides completion of development work by presenting structured options for merge, PR, or cleanup
tooluniverse-variant-interpretation
Systematic clinical variant interpretation from raw variant calls to ACMG-classified recommendations with structural impact analysis. Aggregates evidence from ClinVar, gnomAD, CIViC, UniProt, and PDB across ACMG criteria. Produces pathogenicity scores (0-100), clinical recommendations, and treatment implications. Use when interpreting genetic variants, classifying variants of uncertain significance (VUS), performing ACMG variant classification, or translating variant calls to clinical actionability.
executing-plans
Use when you have a written implementation plan to execute in a separate session with review checkpoints
tooluniverse-variant-functional-annotation
Comprehensive functional annotation of protein variants — pathogenicity, population frequency, structural context, and clinical significance. Integrates ProtVar (map_variant, get_function, get_population) for protein-level mapping and structural context, ClinVar for clinical classifications, gnomAD for population frequency with ancestry data, CADD for deleteriousness scores, and ClinGen for gene-disease validity. Produces a structured variant annotation report with evidence grading. Use when asked about protein variant impact, missense variant pathogenicity, ProtVar annotation, variant functional context, or combining population and structural evidence for a variant.
dispatching-parallel-agents
Use when facing 2+ independent tasks that can be worked on without shared state or sequential dependencies
tooluniverse-variant-analysis
Use when parsing VCF files, filtering variants, annotating mutation consequences, or interpreting SNVs, indels, CNVs, and structural variants.
brainstorming
Use before creative work — creating features, building components, adding functionality, or modifying behavior — to explore user intent, requirements, and design before implementation. One question at a time; 2–3 approaches; design validated in sections.
tooluniverse-vaccine-design
Design and evaluate vaccine candidates using computational immunology tools. Covers epitope prediction (MHC-I/II binding via IEDB), population coverage analysis, antigen selection, adjuvant matching, and immunogenicity assessment. Integrates IEDB for epitope prediction, UniProt for antigen sequences, PDB/AlphaFold for structural epitopes, BVBRC for pathogen proteomes, and literature for clinical precedent. Use when asked about vaccine design, epitope prediction, immunogenicity, MHC binding, T-cell epitopes, B-cell epitopes, or population coverage for vaccine candidates.
th-workflow
Use for the day-to-day development workflow around a change, idea to merged branch: brainstorming intent and design before building or modifying a feature; executing a written implementation plan in checkpointed batches; dispatching parallel subagents for independent problems; requesting a code review before merge; verifying review feedback before acting on it; finishing a branch (merge, PR, keep, discard). Triggers: "brainstorm this feature", "design before building", "execute this plan", "these failures look independent", "request a review", "the reviewer says", "merge or PR?", "clean up this branch".
tooluniverse-toxicology
Assess chemical and drug toxicity via adverse outcome pathways, real-world adverse event signals, and toxicogenomic evidence. Integrates AOPWiki (AOPWiki_list_aops, AOPWiki_get_aop) for mechanism- level pathway tracing, FAERS for post-market adverse event quantification, OpenFDA for label mining, and CTD for chemical-gene-disease evidence. Produces structured toxicity reports with evidence grading (T1-T4). Use when asked about toxicity mechanisms, adverse outcome pathways, AOP mapping, FAERS signal detection, or chemical-disease relationships for drugs or environmental chemicals.
user-run-scripts
Use whenever a task needs something the agent's own sandbox cannot do — an interactive sudo/root password, another TTY prompt, an action blocked by sandbox or permission policy, or any manual out-of-band step (e.g. a 2FA code) — by handing the user a script to run themselves and reading its output back from disk instead of a copy/paste round-trip. Not for commands the agent can already run itself. Triggers: "I need sudo for this", "this needs your password", "run this yourself", "needs an interactive terminal", "sandbox won't let me do X".
tooluniverse-target-research
Gather comprehensive biological target intelligence from 9 parallel research paths covering protein info, structure, interactions, pathways, expression, variants, drug interactions, and literature. Features collision-aware searches, evidence grading (T1-T4), explicit Open Targets coverage, and mandatory completeness auditing. Use when users ask about drug targets, proteins, genes, or need target validation, druggability assessment, or comprehensive target profiling.
transcript-retention
Use to manage the disk footprint of AI-tool session state — Claude Code transcripts (~/.claude/projects), Codex rollouts (~/.codex/sessions), shell snapshots, logs, and sqlite WAL files — by reporting usage and applying an age-based compress/delete policy. Triggers: "how big is my session history", "clean up old transcripts", "codex sessions are eating disk", "transcript retention".
tooluniverse-systems-biology
Comprehensive systems biology and pathway analysis using multiple pathway databases (Reactome, KEGG, WikiPathways, Pathway Commons, BioModels). Performs pathway enrichment, protein-pathway mapping, keyword searches, and systems-level analysis. Use when analyzing gene sets, exploring biological pathways, or investigating systems-level biology.
refresh-snapshots
Use to re-run the harness's snapshot/mirror flows so installed state matches version-controlled source — skill symlinks into ~/.claude, ~/.codex, ~/.gemini tool homes, git submodule pointers, and shell plugin checkouts. Use after restructuring skills, when links look stale or broken, or on a periodic freshness pass. Triggers: "refresh snapshots", "relink skills", "update submodules", "my installed skills are stale".
tooluniverse-structural-variant-analysis
Comprehensive structural variant (SV) analysis skill for clinical genomics. Classifies SVs (deletions, duplications, inversions, translocations), assesses pathogenicity using ACMG-adapted criteria, evaluates gene disruption and dosage sensitivity, and provides clinical interpretation with evidence grading. Use when analyzing CNVs, large deletions/duplications, chromosomal rearrangements, or any structural variants requiring clinical interpretation.
memory-hygiene
Use to compact agent memory stores that grow append-only and rot — AGENTS.md "Notes to self" sections, bd memories, CLAUDE.md instruction drift — by deduplicating, merging superseded entries, and retiring notes whose subject no longer exists. Triggers: "compact my notes to self", "AGENTS.md is huge", "clean up bd memories", "stale agent memory".